Departamento de Fisiopatología

Sepsis

• The role of bundles in sepsis care
  Hurtado FJ, Nin N.
  Crit Care Clin. 2006 Jul;22(3):521-9
  
  
• Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition
  Nin N, Cassina A, Boggia J, Alfonso E, Botti H, Peluffo G, Trostchansky A, Batthyány C, Radi R, Rubbo H, Hurtado FJ.
  Intensive Care Med. 2004 Dec;30(12):2271-8. Epub 2004 Sep 2
  
  
• Salbutamol Improves Diaphragm Force Generation in Experimental Sepsis
  Píriz H, Nin N, Boggia J, Angulo M, Hurtado FJ.
  Arch Bronconeumol. 2008 Mar;44(3):135-139
  
  

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Neumología

• AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis
  Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI.
  J Clin Invest. 2008 Feb;118(2):752-62.
  
  
• High CO2 levels impair alveolar epithelial function independently of pH
  Arturo Briva, István Vadász, Emilia Lecuona, Lynn C. Welch, Jiwang Chen, Laura A. Dada, Humberto E. Trejo, Vidas Dumasius, Zaher S. Azzam, Pavlos M. Myrianthefs, Daniel Batlle, Yosef Gruenbaum, and Jacob I. Sznajder.
  PlosONE, 2007
  
  
• Carbonic Anhydrase II and Alveolar Fluid Reabsorption During Hypercapnia
  Jiwang Chen, Emilia Lecuona, Arturo Briva, Lynn C Welch, and Jacob I Sznajder.
  Am. J. Respir. Cell Mol. Biol., Aug 2007; 10.1165/rcmb.2007-0121OC
  
  
• β−adrenergic receptor stimulation and adenoviral overexpression of sod2 prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption
  Litvan J, Briva A, Wilson MS, Budinger GRS, Sznajder JI, Ridge KM.
  JBC, Jul 2006; 281: 19892 - 19898.
  
  
• Alveolar fluid reabsorption is impaired by hypercapnia independently of extracellular and intracellular pH
  Arturo Briva, Lynn Welch, Jiwang Chen, Pavlos Myrianthefs, Zaher Azzam, Emilia Lecuona, Vidas Dumasius, Daniel Batlle, Yosef Gruenbaum, and Jacob I. Sznajder .
  Chest Meeting Abstracts, Chest 128(4):129S.2005.
  
  
• Hypocapnic but Not Metabolic Alkalosis Impairs Alveolar Fluid Reabsorption
  Myrianthefs PM*, Briva A*, Lecuona E, Dumasius V, Rutschman DH, Ridge KM, Baltopoulos GJ, Sznajder JI.
  Am J Respir Crit Care Med 2005 171:1267–1271.
  
  
• Gene transfer of the Na+,K+-ATPase(beta)1 subunit using electroporation increases lung liquid clearance
  Machado-Aranda D, Adir Y, Young JL, Briva A, Budinger GR, Yeldani AV, Sznajder JI, Dean DA.
  Am J Respir Crit Care Med 2005,171:204–211.
  
  
• Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance
  SloniewskyDE, Ridge KM, Adir Y, Fries FP, Briva A, Sznajder JI, Sporn PH.
  Am J Respir Crit Care Med. 2004 Feb 1;169(3):407-12.
  
  
• Physiologic effects of noninvasive ventilation in patients with chronic obstructive pulmonary disease
  Neme JY, Gutiérrez AM, Santos MC, Berón M, Ekroth C, Arcos JP, Píriz H, Hurtado FJ.
  Arch Bronconeumol. 2007 Mar;43(3):150-5. Spanish. PMID: 17386191
  
  

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Hipertensión

• Is blood pressure during the night more predictive of cardiovascular outcome than during the day?
  Li, Yan a b; Boggia, Jose c; Thijs, Lutgarde a; Hansen, Tine W. e; Kikuya, Masahiro g; Bjorklund-Bodegard, Kristina h; Richart, Tom a; Ohkubo, Takayoshi g; Kuznetsova, Tatiana a; Torp-Pedersen, Christian f; Lind, Lars h; Ibsen, Hans f; Imai, Yutaka g; Wang, Jiguang b; Sandoya, Edgardo d; O'Brien, Eoin i; Staessen, Jan A. a; on behalf of the International Database on Ambulatory Blood Pressure Monitoring in relation to Cardiovascular Outcomes Investigators
  Blood Press Monit. 2008 Jun;13(3):145-147.
  
  
• Putting a spin on the ambulatory arterial stiffness index
  Adiyaman A, Dechering DG, Thien T, Boggia J, Hanssen TW, Li Y, Wang JG, O'Brien, Staessen JA.
  J Hypertens. 2008 Jun;26(6):1266-1267.
  
  
• Diagnostic thresholds for ambulatory blood pressure moving lower: a review based on a meta-analysis-clinical implications
  Hansen TW, Kikuya M, Thijs L, Li Y, Boggia J, Björklund-Bodegârd K, Torp-Pedersen C, Jeppesen J, Ibsen H, Staessen JA.
  J Clin Hypertens (Greenwich). 2008 May;10(5):377-81.
  
  
• Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study
  Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Kuznetsova T, Torp-Pedersen C, Lind L, Ibsen H, Imai Y, Wang J, Sandoya E, O'Brien E, Staessen JA; International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcomes (IDACO) investigators.
  Lancet. 2007 Oct 6;370(9594):1219-29.
  
  
• Dipping deeper into the ambulatory arterial stiffness index
  Adiyaman A, Boggia J, Li Y, Wang JG, O'Brien E, Richart T, Thijs L, Staessen JA.
  Hypertension. 2007 Sep;50(3):e59-60; author reply e61-2. Epub 2007 Jul 16.
  
  

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Cardiología

• Central venous to mixed venous blood oxygen and lactate gradients are associated with outcome in critically ill patients
  Gutierrez G, Comignani P, Huespe L, Hurtado FJ, Dubin A, Jha V, Arzani Y, Lazzeri S, Sosa L, Riva J, Kohn W, Suarez D, Lacuesta G, Olmos D, Mizdraji C, Ojeda A.
  Intensive Care Med. 2008 Apr 30.
  
  
• Comparación del efecto cardioprotector del preacondicionamiento farmacológico con anestésicos halogenados: sevoflurano versus isoflurano in vivo
  Dres. Marcelo Daniel Espiñeira Isabella, Rafael Mila García, Manuel Alberti Correa, Héctor Píriz Abib.
  Rev. Urug. Cardiol. 2007; 22: 116-122
  
  
• Acute cardio-betamodulation enhances left ventricular performance: comparison between oesophageal doppler and invasive pressure-volume derived indexes
  Grignola JC, Devera L, Reta G, Bouchacourt J, Amonte G, Píriz H, Muchada R.
  New Horizons in Coronary Artery Disease. Proceedings of the 7th International Congress on Coronary Artery Disease. 421-25. Venice, ITALY. October 7-10.
  
  
• Improved right ventricular-vascular coupling during active pulmonary hypertension
  Grignola JC, Ginés F, Bia D, Armentano RL.
  Int J Cardiol 115: 171-82.
  
  
• Rol de la arteria pulmonar proximal de conducción en la modulación de la impedancia pulmonar y el acoplamiento ventrículo-arterial
  Grignola JC, Ginés F.
  Sociedad Iberoamericana de Información Científica.
  
  
• Comparison of the Tei index with invasive measurements of right ventricular function
  Grignola JC, Ginés F, Guzzo D.
  Int J Cardiol 113: 25-33
  
  
• Pulmonary artery smooth muscle activation attenuates arterial dysfunction during acute pulmonary hypertension
  Bia D, Barra JG, Grignola JC, Ginés F, Armentano R.
  J Appl Physiol 98(2): 605-613.
  
  
• Cardiovascular Engineering: modelization of ventricular-arterial interaction in systemic and pulmonary circulation
  Craiem D, Graf S, Pessana F, Grignola JC, Bia D, Armentano R.
  Lat Am Appl Res: 35(2): 111-114.
  
  
• Smooth muscle role on pulmonary arterial function during acute pulmonary hypertension in sheep
  Bia D, Armentano R, Craiem D, Grignola J, Ginés F, Simon A, Levenson J.
  Acta Physiol Scand 181: 359-366.
  
  
• Pressure transfer functions to study ventricular-arterial interaction in systemic and pulmonary circulation
  Craiem D, Armentano RL Grignola JC, Bia D, Molas C, Ginés F.
  Proceedings IEEE, v. 1 , p. 383-386.
  
  
• The vascular smooth muscle of large arteries: control local site of the buffering function?
  Bia D, Armentano RL, Grignola JC, Craiem D, Zócalo Y, Ginés F, Levenson J.
  Rev Esp Cardiol 2003, 56: 1202-9.
  
  
• Acute pulmonary hypertension: protective role of vascular smooth muscle activation
  Grignola JC, Bia D, Ginés F, Armentano RL.
  Rev Esp Cardiol 2003, 56: 1077-84.
  
  
• Improved pulmonary artery buffering function during phenylephrine-induced pulmonary hypertension
  Bia D, Grignola JC, Armentano RL, Ginés F.
  Mol Cell Biochem 246:19-24.
  
  

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Nefrología

• Calcium citrate ameliorates the progression of chronic renal injury
  Gadola L, Noboa O, Márquez MN, Rodriguez MJ, Nin N, Boggia J, Ferreiro A, García S, Ortega V, Musto ML, Ponte P, Sesser P, Pizarrosa C, Ravaglio S, Vallega A.
  Kidney Int. 2004 Apr;65(4):1224-30.