Departamento de Fisiopatología
Facultad de Medicina - Universidad de la República
Research
[ español ]
Sepsis
- Sepsis and multiple organ dysfunction. Early goal directed and coadjuvant therapies in sepsis
Dr. Francisco Javier Hurtado Bredda, Prof. Director Fisiopatología
Programa de Desarrollo Tecnológico (PDT)
Septic shock mortality decreased slightly in the last 20 years but remains close to 50 % of the patients. However the understanding of the pathophysiologic mechanisms involved in sepsis and hemodynamic support protocols improved over time... - Vascular dysfunction in sepsis
Dr. Nicolás Nin Vaeza, Prof. Adjunto Fisiopatología
Programa de Desarrollo Tecnológico (PDT)
The incidence of sepsis continues to increase and is the leading cause of death in critically ill patients. In Uruguay the prevalence is of 7/100 patients, with a mortality of 53%...
Nephrology
- Impact of risk factors treatment on the progression rate of chronic kidney disease in glomerulopathies and chronic graft nephropathy
Dra. Liliana Gadola Bergara, Prof. Agregada Fisiopatología
Comisión Sectorial Investigación Científica (CSIC), Proyectos de I+D
Chronic kidney disease is an important health problem worldwide and the replacement therapy (dialysis and transplantation) is very expensive... - Evaluation of kidney oxidative injury in salt sensitive hypertension
Dr. José Boggia, Asistente Fisiopatología
Comisión Sectorial Investigación Científica (CSIC), Modalidad I
Primary hypertension is diagnosed in more than 90 % of patients with high blood pressure, among those more than 50% exhibit salt sensitivity. Despite of the sanitary efforts, hypertension related organ damage is a leader cause of morbidity and mortality in Uruguay and in the occidental world... - Ischemic and pharmacologycal preconditioning on acute kidney injury
Dra. Leonella Luzardo Domenichelli, Asistente interina Fisiopatología
Programa para la Investigación Biomédica - Fundación Manuel Perez - Escuela de Graduados, Facultad de Medicina, Proyecto de Maestría
Ischemic acute kidney injury (AKI), appears in a high percentage of hospitalized patients and it is associated to an increase of the morbimortality; this figure remain high in spite of the technological advances. In addition to ischemia, reperfusion injury amplifies the damage and determines a systemic inflammatory response. ...
Neumology
- Effect of beta adrenergic agonists on hypercapnia-induced alveolar fluid reabsorption impairment
Dr. Arturo Briva, Prof. Adjunto Fisiopatología
Comisión Secorial Investigación Científica (CSIC), Proyectos de I+D
Hypercapnia occurs in a number of lung disease states and usually reflects inadequate gas exchange. However, the effects of high pCO2 contributing to these disease states and the lung epithelium have not been fully elucidated... - A study of pulmonary mechanics and lung surfactant in a model of ventilator induced lung injury produced by high tidal volume
Dr. Manuel Alberti, Ex-Ayudante Fisiopatología
Comisión Secorial Investigación Científica (CSIC), Modalidad I
Our laboratory has developed a ventilator induced lung injury model secondary to high tidal volumes. This model reproduces in the animals the acute respiratory distress syndrome that can be observed in the clinical practice... - Muscular dysfunction in chronic respiratory loading. Effects of salbutamol on injury pathways
Dr. Martín Angulo, Asistente Fisiopatología, Dr. Juan P. Soto, Ayudante Fisiopatología, Dr. Eliseo Taranto, Asistente Fisiopatología
Chronic Obstructive Pulmonary Disease (COPD) represents the fourth leading cause of death in Uruguay and the whole world...
Cardiology
- Effects of levosimendan on right ventricular dysfunction secondary to acute pulmonary embolism: Analysis of the cardiac mechanics and cardiac biomarkers
Dr. Juan Carlos Grignola, Prof. Adjunto Fisiopatología
Comisión Secorial Investigación Científica (CSIC), Proyectos de I+D
The physiological relevance of the right ventricle (RV) was underestimated in the past. Pulmonary embolism (PE) is still being an underdiagnosed and letal disease...
Immunohematology
- Differential gene expression in Chronic Lymphocytic Leukemia and its utility as new prognostic factors
Dr. Sergio Bianchi Cantera, Asistente Fisiopatología
Comisión Secorial Investigación Científica (CSIC), Proyectos de I+D
B-cell Chronic Lymphocytic Leukemia (B-CLL) is the most common adult human leukemia occurring in western countries. Of unknown etiology, B-CLL is characterized by slow and progressive accumulation of small mature B lymphocytes...